From his first ever guest (Bill Murray) in 1982 to that time he interviewed Boris Johnson about the Islamic State, Letterman has been making the whole world laugh as a stalwart of US late-night TV.
Before the world's most committed satirist takes over the show, celebrities, brands and politicians who grew up watching Letterman took the opportunity to pay tribute.
TV won't be the same without Dave. pic.twitter.com/9q5NHTf3b5— Barack Obama (@BarackObama) May 20, 2015
That was a perfect final episode. #ThanksDave— billy eichner (@billyeichner) May 21, 2015
Thanks, Dave. pic.twitter.com/fOgm0uaWVO— Kat Dennings (@OfficialKat) May 20, 2015
Well hell, I cried my eyes out #ThanksDave— Bridey Lee Elliott (@brideylee) May 21, 2015
I already miss David Letterman... #legendary— Neil Patrick Harris (@ActuallyNPH) May 21, 2015
#ThanksDave for making childhood/teenage/adult insomnia fun.— Jeff Rosenstock (@jeffrosenstock) May 21, 2015
Here we go one last time. #ThanksDave— Tom Arnold (@TomArnold) May 21, 2015
He hasn't said a word and I'm crying. #ThanksDave— Elizabeth Banks (@ElizabethBanks) May 21, 2015
It's absolutely absurd to thank David Letterman for all he's done in a tweet. But that's the world we live in now. #ThanksDave— Conan O'Brien (@ConanOBrien) May 21, 2015
Just realized that for the first time in 30 years it's unclear who the funniest person in the world is. #ThanksDave— Chris Gethard (@ChrisGethard) May 21, 2015
That was the perfect last show. #ThanksDave— Shannon O'Neill (@spotastic) May 21, 2015
Honored to have been a part of the show. If you rethink retirement, the job's open. #ThanksDave— Taco Bell (@tacobell) May 21, 2015
'The Late Show' is set to broadcast again under the stewardship of political satire genius Stephen Colbert, premiering for the first time in September 2015.
Here's a preview of what we're in for: